Chromosome analysis in polyploid human embryos
نویسندگان
چکیده
منابع مشابه
Chromosome abnormalities in human embryos.
The presence of numerical chromosome abnormalities in human embryos was studied using fluorescence in-situ hybridization with four or more chromosome-specific probes. When most cells of an embryo are analysed, this technique allows differentiation to be made between aneuploidy, mosaicism, haploidy and polyploidy. Abnormal types of fertilization, such as unipronucleated, tripronucleated zygotes ...
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The homologues in polyploid metaphases of air-dried suspensions of cultured cells are usually seen closely paired as diplochromosomes ("endore duplicated" cells) or unpaired as randomly distributed chromosomes ("poly ploid" cells). More often we find another configuration, a mixture of paired and unpaired chromosomes in the same metaphase, and describe here the conditions under which it appears...
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Mosaicism was studied in good quality embryos from four different centres in order to assess the effects of follicular induction and exposure to laboratory conditions on chromosomal status. The donated embryos were fully biopsied and analysed by fluorescence in-situ hybridization using probes for chromosomes X, Y, 13, 18 and 21, simultaneously. The number of abnormal cells present indicated the...
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X chromosome inactivation (XCI) is the mammalian mechanism that compensates for the difference in gene dosage between XX females and XY males. Genetic and epigenetic regulatory mechanisms induce transcriptional silencing of one X chromosome in female cells. In mouse embryos, XCI is initiated at the preimplantation stage following early whole-genome activation. It is widely thought that human em...
متن کاملChromosome abnormalities in 1255 cleavage-stage human embryos.
The relationship was examined between chromosome abnormalities in cleavage stage human embryos and maternal age, embryo morphology and development rate. Embryos that were classified as suboptimal for transfer from patients undergoing IVF treatment were disaggregated, and all or most of their cells were fixed for analysis by fluorescence in-situ hybridization. Chromosomes X, Y, 13, 18 and 21, an...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 1986
ISSN: 1460-2350,0268-1161
DOI: 10.1093/oxfordjournals.humrep.a136393